Inflammatory markers in the nasal mucosa and polyp-modified tissues in chronic rhinosinusitis with nasal polyps

Introduction. To date, chronic rhinosinusitis with nasal polyps (CRSwNP) has not yet been extensively studied: the molecular factors and mechanisms involved in initiation of polypous transformations mucosa (NM) sustaining their recurrence probability are still to be determined. Simultaneously, it is necessary understand rearrangement NM tissues make clinical prognosis choose an adequate therapeutic or surgical strategy for CRSwNP treatment. The aim study was identify features how inflammatory markers localize distributed various morphological types. Materials methods. We studied chemical structure inferior turbinates. material obtained during management patients diagnosed CRSwNP. comparison group a deviated septum who underwent septorhi-noplasty had neither polyposis nor concomitant inflammatory/allergic pathology. removed surgeries used compare changes. Immunohistochemistry applied determine localization distribution SP, NK1, nNOS, iNOS, IL1b tissues. Results. formation found accompanied by altera-tions mucous membrane In different types, changes activity were specific. Conclusion. data indicate that turbinates, which accompany development, give certain pathological causes induce maintain process. have revealed specific signaling microenvironment cavity, provide special conditions specificity distribu-tion types may serve as prerequisite development personalized therapy disease. Keywords: polyps, inflammation, neurokinin receptors, substance P, nitric oxide